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Sci. STKE, 11 June 2002
Vol. 2002, Issue 136, p. pe28
[DOI: 10.1126/stke.2002.136.pe28]

PERSPECTIVES

KSR--A Regulator and Scaffold Protein of the MAPK Pathway

Thomas Raabe* and Ulf R. Rapp*

University of Würzburg, Institut fuer Medizinische Strahlenkunde und Zellforschung (MSZ), Versbacherstrasse 5, 97078 Würzburg, Germany.

Abstract: Raabe and Rapp discuss how the scaffolding proteins may spatially localize mitogen-activated protein kinase (MAPK) signaling cassettes to allow signaling specificity. They focus on the adaptor kinase suppressor of Ras (KSR) and describe how the interactions between KSR and other proteins and the subcellular localization of KSR are regulated by phosphorylation.

*Corresponding authors. Telephone, +49-931-20145841; fax, +49-931-20145835; e-mail, raabe{at}biozentrum.uni-wuerzburg.de, rappur{at}mail.uni-wuerzburg.de

Citation: T. Raabe, U. R. Rapp, KSR--A Regulator and Scaffold Protein of the MAPK Pathway. Sci. STKE 2002, pe28 (2002).

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