|
Sci. STKE, 11 June 2002 EDITORS' CHOICENEUROBIOLOGY Assessing CNS Axon RegenerationNeurons of the central nervous system (CNS) are much less able to repair themselves after damage than are neurons of the peripheral nervous system. The causes might lie with the differences in environment and type of surrounding glia, or with the neurons themselves. Goldberg et al. (see the Perspective by McKerracher and Ellezam) have isolated retinal ganglion cells, which form part of the CNS, from the rat to study their ability to regenerate axons. RGCs isolated from embryonic rats showed a much greater capability for axon regeneration than did RGCs from early postnatal rats. The diminishing capacity for axonal regeneration correlated with developmental times at which the RGC axons would normally have reached their targets and switched from axonal growth to dendrite elaboration. The switch in growth mode was not related to intrinsic cell age but rather arose from signals from neighboring retinal cells. J. L. Goldberg, M. P. Klassen, Y. Hua, B. A. Barres, Amacrine-signaled loss of intrinsic axon growth ability by retinal ganglion cells. Science 296, 1860-1864 (2002). [Abstract] [Full Text] L. McKerracher, B. Ellezam, Putting the brakes on regeneration. Science 296, 1819-1820 (2002). [Summary] [Full Text]
Citation: Assessing CNS Axon Regeneration. Sci. STKE 2002, tw205 (2002). |
Science Signaling. ISSN 1937-9145 (pre-2008: Science's STKE. ISSN 1525-8882)
Magazine | News | Signaling | Careers | Multimedia | Collections | Help | Site Map | RSS
Subscribe | Feedback | Privacy / Legal | About Us | Advertise With Us | Contact Us
© 2002 American Association for the Advancement of Science. All Rights Reserved.
AAAS is a partner of HINARI, AGORA, PatientInform, CrossRef, and COUNTER.
You have reached the bottom of the page. Back to top