Sci. STKE, 11 June 2002
Neurobiology Reassessing Hippocampal Mossy Fiber LTP
It has become generally agreed that the expression of long-term potentiation (LTP) at mossy fiber-CA3 synapses in the hippocampus is a presynaptic phenomenon. The LTP induction site, however, is still controversial. Contractor et al. used intracellular infusion of peptides and antibodies, as well as extracellular ligand application, to demonstrate a role of postsynaptic interaction of GRIP protein with ephrin B receptors in the induction of LTP. Their data suggest that a retrograde signaling pathway, an ephrin B receptor-B ephrin ligand interaction, links postsynaptic induction with presynaptic expression of long-term changes in neurotransmitter release probability.
A. Contractor, C. Rogers, C. Maron, M. Henkemeyer, G. T. Swanson, S. F. Heinemann, Trans-synaptic Eph receptor-ephrin signaling in hippocampal mossy fiber LTP. Science 296, 1864-1869 (2002). [Abstract] [Full Text]
Citation: Reassessing Hippocampal Mossy Fiber LTP. Sci. STKE 2002, tw208 (2002).
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