Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. STKE, 18 June 2002
Vol. 2002, Issue 137, p. re8
[DOI: 10.1126/stke.2002.137.re8]

REVIEWS

Homer as Both a Scaffold and Transduction Molecule

Laurent Fagni1*, Paul F. Worley2, and Fabrice Ango3

1UPR CNRS 9023, CCIPE, 141 Rue de la Cardonille, 34094 Montpellier, France.
2Department of Neurosciences, The John Hopkins University School of Medicine, Baltimore, MD 21205, USA.
3Cold Spring Harbor Laboratory, Beckman Building, One Bungtown Road, Cold Spring Harbor, NY 11724, USA.

Abstract: Increasing evidence shows that scaffold proteins not only control membrane assembly of receptors and channels, but also modulate intracellular signaling by assembled receptors. The Homer family of proteins act as scaffolds to bind clusters of proteins and glutamate receptors at postsynaptic sites. We review results of cloning and gene expression of this protein family, and summarize roles in glutamate receptor function and intracellular signaling in neurons. Homer proteins trigger the localization of metabotropic glutamate receptor subtype 5 (mGlu5 receptor) to the postsynaptic plasma membrane. They can also alter the kinetics and peak amplitude of the intracellular Ca2+ responses of mGlu1 and mGlu5 receptors. Homer proteins can either prevent or promote spontaneous activation of these receptors, depending on the type of Homer protein isoform expressed.

*Corresponding author. E-mail: fagni{at}montp.inserm.fr

Citation: L. Fagni, P. F. Worley, F. Ango, Homer as Both a Scaffold and Transduction Molecule. Sci. STKE 2002, re8 (2002).

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Dynamic remodeling of scaffold interactions in dendritic spines controls synaptic excitability.
E. Moutin, F. Raynaud, J. Roger, E. Pellegrino, V. Homburger, F. Bertaso, V. Ollendorff, J. Bockaert, L. Fagni, and J. Perroy (2012)
J. Cell Biol. 198, 251-263
   Abstract »    Full Text »    PDF »
Tamalin Is a Critical Mediator of Electroconvulsive Shock-Induced Adult Neuroplasticity.
S. U. Yanpallewar, C. A. Barrick, M. E. Palko, G. Fulgenzi, and L. Tessarollo (2012)
J. Neurosci. 32, 2252-2262
   Abstract »    Full Text »    PDF »
Extinction Training after Cocaine Self-Administration Induces Glutamatergic Plasticity to Inhibit Cocaine Seeking.
L. A. Knackstedt, K. Moussawi, R. Lalumiere, M. Schwendt, M. Klugmann, and P. W. Kalivas (2010)
J. Neurosci. 30, 7984-7992
   Abstract »    Full Text »    PDF »
Metabotropic Glutamate Receptor-Mediated Long-Term Depression: Molecular Mechanisms.
C. M. Gladding, S. M. Fitzjohn, and E. Molnar (2009)
Pharmacol. Rev. 61, 395-412
   Abstract »    Full Text »    PDF »
NFAT Binding and Regulation of T Cell Activation by the Cytoplasmic Scaffolding Homer Proteins.
G. N. Huang, D. L. Huso, S. Bouyain, J. Tu, K. A. McCorkell, M. J. May, Y. Zhu, M. Lutz, S. Collins, M. Dehoff, et al. (2008)
Science 319, 476-481
   Abstract »    Full Text »    PDF »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882