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Sci. STKE, 2 July 2002
Vol. 2002, Issue 139, p. pe31
[DOI: 10.1126/stke.2002.139.pe31]

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Microtubule-Actin Cross-talk at Focal Adhesions

Alexander F. Palazzo1 and Gregg G. Gundersen1,2*

1Department of Anatomy and Cell Biology, Columbia University, New York, NY 10032, USA.
2Department of Pathology, Columbia University, New York, NY 10032, USA.

Abstract: Focal adhesions are dynamic structures in which traction forces are exerted against the substratum during cell migration and are sites for the organization of signaling complexes. Palazzo and Gundersen discuss how focal adhesions may also be the site of cross-talk between the actin-based and microtubule-based cytoskeletons. Microtubules appear to deliver factors that can regulate the formation and dissolution of focal adhesions, whereas focal adhesions contribute to microtubule localization and stability.

*Corresponding author. Telephone, 212-305-1899; fax, 212-305-3970; e-mail, ggg1{at}columbia.edu

Citation: A. F. Palazzo, G. G. Gundersen, Microtubule-Actin Cross-talk at Focal Adhesions. Sci. STKE 2002, pe31 (2002).

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