Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Sci. STKE, 2 July 2002
Vol. 2002, Issue 139, p. pe31
[DOI: 10.1126/stke.2002.139.pe31]

PERSPECTIVES

Microtubule-Actin Cross-talk at Focal Adhesions

Alexander F. Palazzo1 and Gregg G. Gundersen1,2*

1Department of Anatomy and Cell Biology, Columbia University, New York, NY 10032, USA.
2Department of Pathology, Columbia University, New York, NY 10032, USA.

Summary: Focal adhesions are dynamic structures in which traction forces are exerted against the substratum during cell migration and are sites for the organization of signaling complexes. Palazzo and Gundersen discuss how focal adhesions may also be the site of cross-talk between the actin-based and microtubule-based cytoskeletons. Microtubules appear to deliver factors that can regulate the formation and dissolution of focal adhesions, whereas focal adhesions contribute to microtubule localization and stability.

*Corresponding author. Telephone, 212-305-1899; fax, 212-305-3970; e-mail, ggg1{at}columbia.edu

Citation: A. F. Palazzo, G. G. Gundersen, Microtubule-Actin Cross-talk at Focal Adhesions. Sci. STKE 2002, pe31 (2002).

Read the Full Text

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Activation of Endogenous Cdc42 Visualized in Living Cells.
P. Nalbant, L. Hodgson, V. Kraynov, A. Toutchkine, and K. M. Hahn (2004)
Science 305, 1615-1619
   Abstract »    Full Text »    PDF »

ADVERTISEMENT
Click Me!

ADVERTISEMENT

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (pre-2008: Science's STKE. ISSN 1525-8882)