Sci. STKE, 23 July 2002
Cell Biology Not Too Big, Not Too Small
A brute-force approach has been used to address a classic problem in cell biology--how cell growth and the cell division cycle are coordinated so that cells maintain a certain size. Jorgensen et al. (see the Perspective by Sudbery) performed a systematic analysis of the complete set of yeast haploid deletion strains that yielded strains (several thousand) that were either larger or smaller than their normal counterparts. Further genetic analysis revealed a dozen new regulators of Start, the point in the yeast cell cycle at which the cell commits to a new round of cell division. The groups of genes identified point to a key role of nucleolar genes and genes affecting ribosome biogenesis in control of cell size, as well as cell growth.
Citation: Not Too Big, Not Too Small. Sci. STKE 2002, tw265 (2002).
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