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Sci. STKE, 6 August 2002
Vol. 2002, Issue 144, p. pe35
[DOI: 10.1126/stke.2002.144.pe35]

PERSPECTIVES

CD28 Costimulation: A Source of Vav-1 for TCR Signaling with the Help of SLP-76?

Frédérique Michel* and Oreste Acuto

Molecular Immunology Unit, Department of Immunology, Institut Pasteur, 25, rue du Dr. Roux, 75724 Paris, Cedex 15, France.

Abstract: T cells require dual stimulation to become activated. When T cells encounter antigen-presenting cells, both the T cell receptor (TCR) and the CD28 coreceptor are ligated and activated. Michel and Acuto discuss how the adaptor SLP-76, which is recruited to the activated TCR complex, and the Rho family guanosine triphosphatase exchanger Vav-1, which is recruited by the CD28 receptor and TCR, may form a macromolecular complex that results in T cells activation. Vav-1 may serve as a central integrator between CD28 signaling and TCR signaling through its indirect effects on phosphoinositide 3-kinase-dependent signaling.

*Corresponding author. Telephone, 33-1-4568-8638; fax, 33-1-4061-3204; e-mail: fmichel{at}pasteur.fr

Citation: F. Michel, O. Acuto, CD28 Costimulation: A Source of Vav-1 for TCR Signaling with the Help of SLP-76? Sci. STKE 2002, pe35 (2002).

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