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Sci. STKE, 13 August 2002
Vol. 2002, Issue 145, p. pe36
[DOI: 10.1126/stke.2002.145.pe36]

PERSPECTIVES

The Two Hats of SOS

Anjaruwee Nimnual and Dafna Bar-Sagi*

Department of Molecular Genetics and Microbiology, State University of New York at Stony Brook, Stony Brook, NY 11794, USA.

Summary: Son of sevenless (SOS) is a guanine nucleotide exchange factor that activates Ras in response to growth factor stimulation. SOS also appears to serve as a guanine nucleotide exchanger for Rac and, thus, may be involved in cytoskeleton reorganization. Nimnual and Bar-Sagi discuss how these two activities of SOS can be regulated and how SOS may be recruited to different cellular locations through interactions with the adaptor proteins Grb2 and E3b1.

*Corresponding author. E-mail: barsagi{at}pharm.sunysb.edu

Citation: A. Nimnual, D. Bar-Sagi, The Two Hats of SOS. Sci. STKE 2002, pe36 (2002).

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