Sci. STKE, 13 August 2002
Cell Migration Chemokines Direct Glial Cells
The organization of the central nervous system (CNS) is complex and requires a finely tuned balance of attractant and repulsive signals for both the neurons and the glia. Tsai et al. determined that the chemokine CXCL1 and its receptor CXCR2 are essential for the proper migration of oligodendrocytes, which are the glial cells responsible for myelination, in the developing CNS. CXCL1 inhibited migration of platelet-derived growth factor-stimulated oligodendrocyte precursor cell (OPC) and promoted cell adhesion in culture. In slice preparations, CXCL1 addition inhibited dorsal migration of the OPCs. In CXCR2-/- mice, there were fewer OPCs in the developing spinal cord, and their position was displaced toward the pial surface. Finally, experiments in which wild-type or CXCR2-/- OPCs were injected into wild-type or CXCR2-/- spinal cord slices confirmed the migration-inhibiting properties of CXCR2 signaling. Thus, chemokines continue to emerge as important migratory control signals in the developing nervous system.
H.-H. Tsai, E. Frost, V. To, S. Robinson, C. ffrench-Constant, R. Geertman, R. M. Ransohoff, R. H. Miller, The chemokine receptor CXCR2 controls positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. Cell 110, 373-383 (2002). [Online Journal]
Citation: Chemokines Direct Glial Cells. Sci. STKE 2002, tw299 (2002).
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