IMMUNOLOGY Maintaining Immunity

Phosphoinositide 3-kinase activity regulates many cell processes across many cell types. There are three isoforms of its catalytic subunit p110, but their specificity has not been clear. Okkenhaug et al. generated a mouse that expresses an inactive form of p110 and observed compromised B and T cell immune function. The study reveals a highly selective, nonredundant role for this isoform in lymphocyte antigen receptor signaling, as well as a drug-development target.

K. Okkenhaug, A. Bilancio, G. Farjot, H. Priddle, S. Sancho, E. Peskett, W. Pearce, S. E. Meek, A. Salpekar, M. D. Waterfield, A. J. H. Smith, B. Vanhaesebroeck, Impaired B and T cell antigen receptor signaling in p110 PI 3-kinase mutant mice, Science 297, 1031-1034 (2002). [Abstract] [Full Text]

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In Science Signaling

PERSPECTIVES
New Responsibilities for the PI3K Regulatory Subunit p85

Klaus Okkenhaug and Bart Vanhaesebroeck (16 January 2001)
Sci. STKE 2001 (65), pe1. [DOI: 10.1126/stke.2001.65.pe1]
 |  Abstract »  |  Full Text »  |  PDF »

In Science Magazine

REPORTS
Impaired B and T Cell Antigen Receptor Signaling in p110 PI 3-Kinase Mutant Mice

Klaus Okkenhaug, Antonio Bilancio, Géraldine Farjot, Helen Priddle, Sara Sancho, Emma Peskett, Wayne Pearce, Stephen E. Meek, Ashreena Salpekar, Michael D. Waterfield, Andrew J. H. Smith, and Bart Vanhaesebroeck (9 August 2002)
Science 297 (5583), 1031. [DOI: 10.1126/science.1073560]
 |  Abstract »  |  Full Text »  |  PDF »  |  Supporting Online Material »