Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. STKE, 27 August 2002
Vol. 2002, Issue 147, p. tw317
[DOI: 10.1126/stke.2002.147.tw317]

EDITORS' CHOICE

Meiosis Starts and Stops

In the mammalian ovarian follicle, several layers of somatic granulosa cells surround the oocyte and support its development. Within this structure, the oocyte begins meiosis, but then halts until luteinizing hormone triggers its resumption. How is meiosis halted? Studies to answer this question have been hampered in that removal of the follicle from an oocyte reinitiates meiosis. However, Mehlmann et al. now present a technique in which oocytes can be injected while still surrounded by the follicular cells. The authors show that activity of the G protein Gs is required to maintain the meiotic arrest in oocytes, and they suggest that a signal from granulosa cells may be acting through a receptor to activate the G protein.

L. M. Mehlmann, T. L. Z. Jones, L. A. Jaffe, Meiotic arrest in the mouse follicle maintained by a Gs protein in the oocyte, Science 297, 1343-1345 (2002). [Abstract] [Full Text]

Citation: Starts and Stops. Sci. STKE 2002, tw317 (2002).



To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882