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Sci. STKE, 27 August 2002 EDITORS' CHOICECELL BIOLOGY Persistent Pores in Insulin SecretionDuring stimulated secretion, a secretory granule fuses with the plasma membrane to release secretory granule contents. Takahashi et al. have used two-photon excitation imaging to reveal the dynamics of the fusion pore during insulin secretion from pancreatic islets. The lifetime of the pore, which was made up mostly of membrane lipids, was much longer than anticipated from other studies with single cells. N. Takahashi, T. Kishimoto, T. Nemoto, T. Kadowaki, H. Kasai, Fusion pore dynamics and insulin granule exocytosis in the pancreatic islet, Science 297, 1349-1352 (2002). [Abstract] [Full Text]
Citation: Persistent Pores in Insulin Secretion. Sci. STKE 2002, tw318 (2002). The editors suggest the following Related Resources on Science sites:In Science Magazine
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