Sci. STKE, 27 August 2002
Neurobiology Prince of Dendrites?
Neurons obtain signaling information through their dendrites, which may range in structure from simple thin extensions of the cell body to complex branched outreaches. Studying the ventral pore sensory organs of fruit fly, Moore et al. find that the complexity of the dendritic arbor is regulated by a single gene, hamlet. Genetic manipulations that raised or decreased hamlet protein expression from its normal levels caused the local progenitor cell to produce neurons with single dendrites or with complex dendritic arbors during the early stages of neuronal development. Analyses of the gene sequence and subcellular localization suggest that hamlet might encode a transcription factor.
Citation: Prince of Dendrites? Sci. STKE 2002, tw319 (2002).
Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882