Sci. STKE, 10 September 2002
Apoptosis Cadherins Regulate Cell Survival
Cell-matrix and cell-cell adhesions are important regulators of cell survival. Modulation of either can result in tumor formation and metastasis. The former is regulated by cell-surface integrins, whereas contact between adjacent cells is mediated by cell-surface cadherins. How cadherins control cell survival has not been clear. Increased expression of N-cadherin has been associated with increased invasiveness and cell survival of some carcinomas. Tran et al. report that this may be due stabilization of the antiapoptotic protein Bcl-2. In the absence of integrin-mediated adhesion and growth factors, prostate carcinoma cells in suspension suppressed cell death. This was dependent on cell-cell adhesion through N-cadherin and correlated with increased activation of phosphatidylinositol 3-kinase and the serine-threonine kinase Akt. Intercellular adhesion also induced increased Bcl-2 expression. The survival pathway initiated by integrins also converges on Akt, which suggests overlap between the two adhesion-dependent pathways.
Citation: Cadherins Regulate Cell Survival. Sci. STKE 2002, tw333 (2002).
Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882