Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. STKE, 29 October 2002
Vol. 2002, Issue 156, p. tw394
[DOI: 10.1126/stke.2002.156.tw394]

EDITORS' CHOICE

Systems Biology Transcriptional Networks and Their Relatives

Living cells are the product of gene expression programs involving regulated transcription of thousands of genes. Lee et al. used immunoprecipitation and microarray studies to build a global analysis of transcriptional regulatory networks in Saccharomyces cerevisiae. Patterns observed were characterized as motifs that were then combined by an automatic process into a network structure. Such transcriptional regulation represents a network of interactions, and similar networks underlie apparently unrelated systems, such as food webs and electronic circuits. To examine their fundamental design features, Milo et al. (see the Perspective by Oltvai and Barabási) looked at local organizing principles of networks, expressed as motifs of how different interactors are joined, that occurred at more than random frequencies. Motifs shared by food webs had features that were not shared by transcription networks from yeast and from Escherichia coli or by electronic circuits, although similarities were seen in information-processing circuits.

T. I. Lee, N. J. Rinaldi, F. Robert, D. T. Odom, Z. Bar-Joseph, G. K. Gerber, N. M. Hannett, C. T. Harbison, C. M. Thompson, I. Simon, J. Zeitlinger, E. G. Jennings, H, L. Murray, D. B. Gordon, B. Ren, J. J. Wyrick, J.-B. Tagne, T. L. Volkert, E. Fraenkel, D. K. Gifford, R. A. Young, Transcriptional regulatory networks in Saccharomyces cerevisiae. Science 298, 799-804 (2002). [Abstract] [Full Text]

R. Milo, S. Shen-Orr, S. Itzkovitz, N. Kashtan, D. Chklovskii, U. Alon, Network motifs: Simple building blocks of complex networks. Science 298, 824-827 (2002). [Abstract] [Full Text]

Z. N. Oltvai, A.-L. Barabási, Life's complexity pyramid. Science 298, 763-764 (2002). [Summary] [Full Text]

Citation: Transcriptional Networks and Their Relatives. Sci. STKE 2002, tw394 (2002).



To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882