Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. STKE, 29 October 2002
Vol. 2002, Issue 156, p. tw395
[DOI: 10.1126/stke.2002.156.tw395]

EDITORS' CHOICE

Insulin Signaling Live Long and Reproduce

Insulin and other insulin-like growth factors signal through a pathway that involves phosphatidylinositol 3-kinase and the forkhead transcription factors. This pathway is a critical regulator of life-span and reproduction in many organisms. Dillin et al. have now determined that in the nematode Caenorhabditis elegans, life-span can be regulated through this pathway only in the adult and reproduction only in the developmental phases. Thus, the long-standing notion that life-span can be lengthened only at the expense of reproductive fitness is almost certainly false.

A. Dillin, D. K. Crawford, C. Kenyon, Timing requirements for Insulin/IGF-1 signaling in C. elegans. Science 298, 830-834 (2002). [Abstract] [Full Text]

Citation: Live Long and Reproduce. Sci. STKE 2002, tw395 (2002).



To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882