Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Sci. STKE, 5 November 2002
Vol. 2002, Issue 157, p. tw406
[DOI: 10.1126/stke.2002.157.tw406]


Parasitology Taking Advantage of the Host

The tick-borne protozoan parasites Theileria spp. (related to the malaria parasites, Plasmodium spp.) cause a cancer-like disease in cattle that is of major economic importance in Africa and Asia. Heussler et al. show how this pathogen subverts its host's signaling pathway for its own good. The schizont stage of the parasite infects the B and T cells of the immune system and immortalizes them into tumor-like cells capable of metastasis. Transformation seems to occur because the parasite activates the nuclear factor-{kappa}B (NF-{kappa}B) pathway and prevents apoptosis. This activation cannot be blocked by treatment with drugs that affect steps in the NF-{kappa}B signaling pathway upstream of multisubunit I{kappa}B kinase (IKK). The authors show that the intracellular foci of Theileria are associated with recruitment and aggregation of the IKK signalsome complex. Such aggregation seems to be sufficient to activate the kinase and subsequently activate NF-{kappa}B.

V. T. Heussler, S. Rottenberg, R. Schwab, P. Küenzi, P. C. Fernandez, S. McKellar, B. Shiels, Z. J. Chen, K. Orth, D. Wallach, D. A. E. Dobbelaere, Hijacking of host cell IKK signalosomes by the transforming parasite Theileria. Science 298, 1033-1036 (2002). [Abstract] [Full Text]

Citation: Taking Advantage of the Host. Sci. STKE 2002, tw406 (2002).

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882