Sci. STKE, 12 November 2002
Transcription Picking a Signaling Pathway
How is specificity gained when numerous genes are regulated by a single transcription factor in response to diverse stimuli? Hoffman et al. (see the Perspective by Ting and Endy) examined how a transcription factor called nuclear factor-B (NF-B) is differentially controlled by three different isoforms of an inhibitor protein called IB. They combined computational modeling with biochemical data that they obtained from genetically engineered cells that express only one IB isoform. During the cell's exposure to a stimulus, a bimodal and temporal signal processing mechanism determines which IB-NF-B pathway and downstream target genes get activated.
Citation: Picking a Signaling Pathway. Sci. STKE 2002, tw417 (2002).
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