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Sci. STKE, 26 November 2002
Vol. 2002, Issue 160, p. tw447
[DOI: 10.1126/scisignal.1602002tw447]

EDITORS' CHOICE

Immunology B Cell Immunodeficiency

Several cytokine receptors utilize the common cytokine receptor {gamma} chain ({gamma}c), and mutations in {gamma}c result in the condition known as X-linked severe combined immunodeficiency (XSCID). Lack of signaling through the interleukin-7 (IL-7) and IL-15 receptors leads to a loss of natural killer and T cells in XSCID patients, although the cause of the B cell defect is not established. Ozaki et al. observed that B cells from mice lacking IL-21 receptor had altered antibody production. When combined with a loss of IL-4 signaling, a severely impaired immunoglobulin G response was observed that is strikingly similar to that seen in XSCID individuals.

K. Ozaki, R. Spolski, C. G. Feng, C.-F. Qi, J. Cheng, A. Sher, H. C. Morse III, C. Liu, P. L. Schwartzberg, W. J. Leonard, A critical role for IL-21 in regulating immunoglobulin production. Science 298, 1630-1634 (2002). [Abstract] [Full Text]

Citation: B Cell Immunodeficiency. Sci. STKE 2002, tw447 (2002).

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