Plasticity of the Kinomes in Monkey and Rat Tissues

doi:10.1126/stke.2002.162.pe50

Account Information

Guest Alerts | Access Rights | My Account | Sign In

Site Navigation

Article Views

Article Tools

Help & Feedback

My Science Signaling

Sci. STKE, 10 December 2002
[DOI: 10.1126/stke.2002.162.pe50]

PERSPECTIVES

Plasticity of the Kinomes in Monkey and Rat Tissues

Steven Pelech¹^,2^* and Hong Zhang¹

¹Kinexus Bioinformatics Corporation, Vancouver, BC, Canada.
²Department of Medicine, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.

Summary: The Kinetworks KPKS 1.0 immunoblotting screen was used to investigate the differential expression of 58 protein serine-threonine kinases, five protein threonine-tyrosine kinases, and 15 other nonreceptor protein tyrosine kinases in three types of human blood cells, 14 monkey organs, and six rat organs. The results demonstrate striking differences in the kineome profiles of diverse organs and even between the same organs in different species.

*Corresponding author. Kinexus Bioinformatics Corporation, Suite 401, 2389 Health Sciences Mall, Vancouver, BC, Canada V6T 1Z4. Telephone, 604-822-9966; fax, 604-822-9964; e-mail: spelech{at}kinexus.ca

Citation: S. Pelech, H. Zhang, Plasticity of the Kinomes in Monkey and Rat Tissues. Sci. STKE 2002, pe50 (2002).

Read the Full Text

The editors suggest the following Related Resources on Science sites:

In Science Signaling

EDITORIAL GUIDES Focus Issue: The Kinome--Techniques and Methods for Analysis: L. Bryan Ray and Nancy R. Gough (10 December 2002)
Sci. STKE 2002 (162), eg13. [DOI: 10.1126/stke.2002.162.eg13]
| Full Text » | PDF »