Sci. STKE, 7 January 2003
Cytoskeleton Transcriptional Regulation via ACTive Transport
Molecules called kinesins are critical for the movement of chromosomes, organelles, and messenger RNAs molecules within cells. Macho et al. now show that the testis-specific kinesin KIF17b can function in the transport of the coactivator ACT and affect transcriptional activity. ACT is a coactivator of CREM-mediated transcription in mammalian spermatids. KIF17b acts as a dose-dependent inhibitor of ACT-dependent transcription by excluding ACT from the nucleus. This work begins to address the molecular mechanism by which germ-cell gene expression is regulated.
B. Macho, S. Brancorsini, G. M. Fimia, M. Setou, N. Hirokawa, P. Sassone-Corsi, CREM-dependent transcription in male germ cells controlled by a kinesin. Science 298, 2388-2390 (2002). [Abstract] [Full Text]
Citation: Transcriptional Regulation via ACTive Transport. Sci. STKE 2003, tw12 (2003).
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