Chromatin A Signal for Remodeling

In eukaryotes, DNA is wrapped around nucleosomes to form a chromatin structure that is molded by adenosine triphosphate-dependent chromatin remodeling complexes in order to facilitate access by transcription factors. Steger et al. and Shen et al. both show that chromatin remodeling complexes can be regulated by small molecules known as inositol polyphosphates, providing a link between second-messenger signaling and nuclear activities.

D. J. Steger, E. S. Haswell, A. L. Miller, S. R. Wente, E. K. O'Shea, Regulation of chromatin remodeling by inositol polyphosphates. Science 299, 114-116 (2003). [Abstract] [Full Text]

X. Shen, H. Xiao, R. Ranallo, W.-H. Wu, C. Wu, Modulation of ATP-dependent chromatin-remodeling complexes by inositol polyphosphates. Science 299, 112-114 (2003). [Abstract] [Full Text]

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REPORTS
Regulation of Chromatin Remodeling by Inositol Polyphosphates

David J. Steger, Elizabeth S. Haswell, Aimee L. Miller, Susan R. Wente, and Erin K. O'Shea (3 January 2003)
Science 299 (5603), 114. [DOI: 10.1126/science.1078062]
 |  Abstract »  |  Full Text »  |  PDF »  |  Supporting Online Material »

REPORTS
Modulation of ATP-Dependent Chromatin-Remodeling Complexes by Inositol Polyphosphates

Xuetong Shen, Hua Xiao, Ryan Ranallo, Wei-Hua Wu, and Carl Wu (3 January 2003)
Science 299 (5603), 112. [DOI: 10.1126/science.1078068]
 |  Abstract »  |  Full Text »  |  PDF »  |  Supporting Online Material »