Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Sci. STKE, 7 January 2003
Vol. 2003, Issue 164, p. tw17
[DOI: 10.1126/stke.2003.164.tw17]


Immunology Switching Signals

B cells mount distinct responses by altering the class of antibody they secrete, and this class switching is also evident at the B cell surface, where membrane-bound antibodies cooperate with common signaling components to form B cell receptors (BCRs). Although these transduction modules are the same in each BCR, one receptor, the immunoglobulin G (IgG)-containing BCR, possesses distinct signaling capabilities from the others. Wakabayashi et al. find that these capabilities arise through the selective activation of CD22, a transmembrane protein known to down-regulate B cell activation. Ligation of IgG-BCR failed to induce both efficient CD22-dependent recruitment of the phosphatase SHP-1 and inhibition of the extracellular signal-regulated kinases (ERK1 and ERK2) and calcium signaling. By protecting itself from the inhibitory effects of CD22, IgG-BCR may regulate efficient class-switching, as well as enhanced responsiveness of IgG+ memory B cells.

C. Wakabayashi, T. Adachi, J. Wienands, T. Tsubata, A distinct signaling pathway used by the IgG-containing B cell antigen receptor. Science 298, 2392-2395 (2002). [Abstract] [Full Text]

Citation: Switching Signals. Sci. STKE 2003, tw17 (2003).

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882