Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. STKE, 7 January 2003
Vol. 2003, Issue 164, p. tw3
[DOI: 10.1126/stke.2003.164.tw3]

EDITORS' CHOICE

Calcium High Frequency Filter for Ca2+

Transient changes in intracellular Ca2+ regulate numerous cellular functions including gene expression. Some Ca2+-mediated changes in gene expression are elicited by increases in cytosolic Ca2+ concentration ([Ca2+]c), whereas others require an increase in nuclear Ca2+ concentration ([Ca2+]n). Chamero et al. expressed targeted aequorins in the cytoplasm and nuclei of bovine adrenal chromaffin cells, PC12 cells, and GH3 cells to measure [Ca2+]c and [Ca2+]n and to study the spread of Ca2+ from the cytoplasm to the nucleus following various stimuli. The authors found that stimuli that produced sustained increases in [Ca2+]c, either through Ca2+ entry or through release from intracellular stores, produced similar changes in [Ca2+]n, whereas brief oscillations in [Ca2+]c visualized in individual GH3 cells were dampened during propagation to the nucleus. These data suggest that a kinetic filter limits the effects of high frequency changes in [Ca2+]i on [Ca2+]n but allows sustained Ca2+ signals through. Such a filter could provide a mechanism whereby Ca2+ signals are encoded; this would allow for the differential regulation of processes that depend on increases in either [Ca2+]c or [Ca2+]n.

P. Chamero, C. Villalobos, M. T. Alonso, J. García-Sancho, Dampening of cytosolic Ca2+ oscillations on propagation to the nucleus. J. Biol. Chem. 277, 50226-50229 (2002). [Abstract] [Full Text]

Citation: High Frequency Filter for Ca2+. Sci. STKE 2003, tw3 (2003).



To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882