Sci. STKE, 7 January 2003
Gene Expression TOR Signals Alter Chromatin
The signaling pathway controlled by the kinase TOR (target of rapamycin) governs cell growth in response to nutrient availability. It accomplishes this in part by inducing the expression of genes encoding ribosomal proteins (RP genes). Rohde and Cardenas report that TOR signaling maintains the presence of a histone acetylase called Esa1 at RP gene promoters. In the absence of TOR signaling, either by nutrient depletion or inhibition of TOR by rapamycin, Esa1 is released from promoters. A deacetylating complex called Rpd3-Sin3, which is already present at RP gene promoters, is then able to inhibit transcription of RP genes. Thus, TOR signaling can regulate growth by altering ribosome biogenesis through modification of chromatin conformation.
Citation: TOR Signals Alter Chromatin. Sci. STKE 2003, tw4 (2003).
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