Sci. STKE, 21 January 2003
Protein Degradation Biting in the Middle
The proteasome is a cylindrical molecular machine that promotes the proteolysis of a wide variety of cellular substrates, including many important signaling mediators and regulators. Its architecture is well understood at the molecular level, and it has been assumed that substrates are threaded into the cylinder from their termini for cleavage. Liu et al. have found that, in vitro, the proteasome can cleave internal sites within a protein and can even cleave circular substrates.
Citation: Biting in the Middle. Sci. STKE 2003, tw37 (2003).
Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882