Sci. STKE, 28 January 2003
Development Changing Where You Send the Bill
Migratory neural crest cells are one of the sources of developmental information that are integrated into the shaping of the head and face. Schneider and Helms (see the Perspective by Trainor) used cellular chimeras of duck and quail to produce "qucks" and "duails" in order to analyze the molecular information exchange that directs beak formation in these birds. The transplanted neural crest cells form the right types of structures in the right locations as required by the host, but the specific form of those structures is directed by the source of the neural crest cells. The transplanted cross-species neural crest cells also directed development of host cranio-facial structures with which they interact. Thus, the final shape of neural crest derivatives in the face is a triple interplay of reciprocating information streams.
Citation: Changing Where You Send the Bill. Sci. STKE 2003, tw45 (2003).
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