Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Sci. STKE, 28 January 2003
Vol. 2003, Issue 167, p. tw48
[DOI: 10.1126/scisignal.1672003tw48]

EDITORS' CHOICE

Chromosomal Puffing How PARP Produces Puffs

Polytene chromosomes in the salivary glands of the fruit fly Drosophila undergo "puffing" at specific regions that often correspond to increased gene expression. Tulin and Spradling (see the Perspective by Pirrotta) now show that ribosylation and poly(ADP-ribose) polymerase (PARP) mediate chromosome puffing. The authors propose that PARP dissociates chromatin proteins at induced chromosomal loci, which then allows increases in transcriptional activity.

A. Tulin, A. Spradling, Chromatin loosening by poly(ADP)-ribose polymerase (PARP) at Drosophila puff loci. Science 299, 560-562 (2003). [Abstract] [Full Text]

V. Pirrotta, Puffing with PARP. Science 299, 528-529 (2003). [Summary] [Full Text]

Citation: How PARP Produces Puffs. Sci. STKE 2003, tw48 (2003).

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882