Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. STKE, 11 February 2003
Vol. 2003, Issue 169, p. tw60
[DOI: 10.1126/stke.2003.169.tw60]

EDITORS' CHOICE

Circadian Rhythms Keeping an Eye on the Master Clock

Lee at al. have described a circadian pattern of mitogen-activated protein kinase (MAPK) phosphorylation in the suprachiasmatic nucleus (SCN) that depends on input from the eye. The SCN functions as the master pacemaker that drives physiological and behavioral circadian rhythms in mammals. Although SCN clocks are reset by environmental inputs such as light, all SCN rhythms are currently believed to be endogenously generated independent of input from outside the SCN. Lee et al. used an antibody specific for the phosphorylated form of the MAPKs extracellular signal-regulated kinase 1 and 2 (ERK) to immunostain sections of hamster SCN at different circadian times. They observed two rhythmic patterns of ERK phosphorylation for hamsters housed in constant dim light. During the subjective day, a shell-like pattern of phosphorylated ERK (pERK) appeared, whereas during subjective night, pERK was only apparent in a core-like pattern within the caudal SCN. Transplanted SCNs, which restored behavioral and physiological rhythmicity to SCN-lesioned hamsters but did not receive the normal neuronal inputs, showed the shell pattern of pERK rhythm but not the core pattern. Similarly, hamsters and mice whose eyes were removed showed behavioral and physiological circadian rhythms but not the core pERK rhythm. Tract-tracing experiments suggested that the pERK cells in the core region received input from cells in the retina. These data suggest that circadian cycling in at least one region of the SCN depends on input from the retina.

H. S. Lee, J. L. Nelms, M. Nguyen, R. Silver, M. N. Lehman, The eye is necessary for circadian rhythm in the suprachiasmatic nucleus. Nature Neurosci. 6, 111-112 (2003). [Online Journal]

Citation: Keeping an Eye on the Master Clock. Sci. STKE 2003, tw60 (2003).


To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882