Sci. STKE, 25 February 2003
Polarity How Cells Put on Caps by Themselves
Cells are generally polarized. How can a single cell, in the absence of external cues, generate a polarized distribution of its constituent parts? Wedlich-Soldner et al. address this question in the yeast Saccharomyces cerevisiae. Overexpression of the protein Cdc42--a protein known to be involved in polarization of mammalian cells--enabled a cell to polarize spontaneously. It seems that random accumulations of the protein get locked into a process of continued accumulation that arises from a positive feedback in protein localization involving actin-based targeted secretion. This process leads to the formation of a cap of the protein at the cell surface that can then go on to promote the polarization of the cell.
Citation: How Cells Put on Caps by Themselves. Sci. STKE 2003, tw87 (2003).
The editors suggest the following Related Resources on Science sites:
In Science Signaling
In Science Magazine
Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882