Sci. STKE, 15 April 2003
IMMUNOLOGY Early Help in Programming Immune Memories
To generate a convincing humoral immune response to infection, most antibody-producing B cells must receive assistance from CD4+ helper T cells. By contrast, the primary response of many CD8+ T lymphocytes shows little dependence on T cell help, and there has been debate whether the same holds true for memory CD8+ T cells. Sun and Bevan and Shedlock and Shen show that vigorous CD8+ T cell memory in mice depends heavily on CD4+ T cell help, although this reliance develops specifically during primary rather than secondary responses. Thus, initial priming of CD8+ T cells to antigen appears to represent a crucial juncture in the production of efficient immunological memory to infection and vaccines.
Citation: Early Help in Programming Immune Memories. Sci. STKE 2003, tw153 (2003).
The editors suggest the following Related Resources on Science sites:
In Science Magazine
Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882