Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. STKE, 6 May 2003
Vol. 2003, Issue 181, p. pe16
[DOI: 10.1126/stke.2003.181.pe16]

PERSPECTIVES

Angiotensin Type 2 Receptor (AT2R): A Challenging Twin

Bradford C. Berk*

Center for Cardiovascular Research and Department of Medicine, University of Rochester, Rochester, NY 14642, USA.

Abstract: Angiotensin II (AngII) regulates such physiological responses as salt and water balance, blood pressure, and vascular tone, and thus plays a critical role in the pathogenesis of diabetes, hypertension, myocardial infarction, congestive heart failure, and stroke. These effects are mediated through at least three receptors: AT1R, AT2R, and AT4R, which are expressed under different developmental, tissue-specific, and disease-specific conditions and which couple to distinct effector pathways. Signaling through the AT1R, a classical G protein-coupled receptor, has been extensively studied and is well understood. Less is known about signaling through the AT2R, which often antagonizes the effects of signaling through the AT1R, but intriguing data are beginning to emerge concerning the signaling strategies and pathways that the AT2R employs.

*Contact information. Center for Cardiovascular Research, University of Rochester Medical Center, Box 679, Rochester, NY 14642, USA. Telephone, 716585-273-1946; fax, 716585-273-1497; e-mail, bradford_berk{at}urmc.rochester.edu

Citation: B. C. Berk, Angiotensin Type 2 Receptor (AT2R): A Challenging Twin. Sci. STKE 2003, pe16 (2003).

Read the Full Text



To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882