Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Sci. STKE, 6 May 2003
Vol. 2003, Issue 181, p. tw181
[DOI: 10.1126/stke.2003.181.tw181]


INTEGRINS Group Activities

Integrins comprise a globular ligand-binding head and two flexible rod-like stalks that contain the transmembrane and cytoplasmic regions of the integrin α and β chains. Although the details of the integrin activation mechanism are controversial, several proposals agree that the stalks splay apart on activation and that integrin activation is accompanied by clustering of the receptors. Li et al. (see the Perspective by Hynes) found two mutations in the transmembrane helix of the β subunit that enhanced the tendency of the β subunit to form homotrimers and that also induced clustering and constitutive phosphorylation of focal adhesion kinase. Homo-oligomerization may drive activation by stabilizing the activated state while simultaneously inducing the formation of clusters.

R. Li, N. Mitra, H. Gratkowski, G. Vilaire, R. Litvinov, C. Nagasami, J. W. Weisel, J. D. Lear, W. F. DeGrado, J. S. Bennett, Activation of integrin αIIbβ3 by modulation of transmembrane helix associations. Science 300, 795-798 (2003). [Abstract] [Full Text]

R. O. Hynes, Changing partners. Science 300, 755-756 (2003). [Summary] [Full Text]

Citation: Group Activities. Sci. STKE 2003, tw181 (2003).

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882