Sci. STKE, 13 May 2003
SYNAPTIC PLASTICITY Creating Left-Right Asymmetry in the Hippocampus
The NR2B subunit of the NMDA receptor is a major prerequisite for learning and memory. A dynamic rearrangement of this subunit occurs during development and after synaptic modifications. Kawakami et al. show that, in the adult mouse hippocampus, the NR2B subunit is asymmetrically distributed in glutamatergic synapses deriving from ipsilateral versus contralateral afferents. There is also an asymmetric NR2B distribution between synapses on the basal and apical dendrites of pyramidal neurons.
R. Kawakami, Y. Shinohara, Y. Kato, H. Sugiyama, R. Shigemoto, I. Ito, Asymmetrical allocation of NMDA receptor 2 subunits in hippocampal circuitry. Science 300, 990-994 (2003). [Abstract] [Full Text]
Citation: Creating Left-Right Asymmetry in the Hippocampus. Sci. STKE 2003, tw186 (2003).
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