Sci. STKE, 20 May 2003
LIFE-SPAN Double-Teaming the Aging Process
Two transcription factors that control longevity in the nematode Caenorhabditis elegans code are HSF-1, which is induced by heat stress, and DAF-16, a member of FOXO family. Hsu et al. show that these transcription factors act together to regulate a set of genes, including those for small heat shock proteins (HSPs), which themselves regulate life-span. These small HSPs may counteract aging effects by binding to damaged proteins and preventing the formation of harmful aggregates.
Citation: Double-Teaming the Aging Process. Sci. STKE 2003, tw199 (2003).
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