Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Sci. STKE, 10 June 2003
Vol. 2003, Issue 186, p. tw225
[DOI: 10.1126/stke.2003.186.tw225]


IMMUNOLOGY The In's and Out's on Pathogen Screening

All multicellular organisms have common families of mechanisms that operate during early stages of responses to pathogen attack. Studies in insects and mammals have revealed the role of the Toll family and of the pattern recognition molecules Nod 1 and 2 in activating similar, but not identical, signal-transduction pathways. Lipopolysaccharide is not the sole pattern recognized by the innate immune system, Girardin et al. show that intracellular Nod1 specifically detects a tripeptide bearing an exposed diaminopimelate amino acid derived from the peptidoglycan of Gram-negative bacteria. In contrast, Nod2, which is present on monocytes, macrophages, and dendritic cells senses a peptidoglycan dipeptide motif common to all bacteria (unresponsive mutants of Nod2 have been implicated in Crohn's disease). Thus, Nod1 allows discrimination between intracellular Gram-positive and Gram-negative microorganisms and helps to shape subsequent adaptive immune responses.

S. E. Girardin, I. G. Boneca, L. A. M. Carneiro, A. Antignac, M. Jéhanno, J. Viala, K. Tedin, M.-K. Taha, A. Labigne, U. Zäthringer, A. J. Coyle, P. S. DiStefano, J. Bertin, P. J. Sansonetti, D. J. Philpott, Nod1 detects a unique muropeptide from Gram-negative bacterial peptidoglycan, Science 300, 1584-1587 (2003). [Abstract] [Full Text]

Citation: The In's and Out's on Pathogen Screening. Sci. STKE 2003, tw225 (2003).

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882