Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. STKE, 17 June 2003
Vol. 2003, Issue 187, p. re9
[DOI: 10.1126/stke.2003.187.re9]


Signaling Receptome: A Genomic and Evolutionary Perspective of Plasma Membrane Receptors Involved in Signal Transduction

Izhar Ben-Shlomo{dagger}, Sheau Yu Hsu, Rami Rauch, Haili W. Kowalski, and Aaron J. W. Hsueh*

Division of Reproductive Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305-5317, USA.
{dagger}Present address: HaEmek Medical Center, Afula, Israel; Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel.

Abstract: Intercellular communication in multicellular organisms requires the relay of extracellular signals by cell surface proteins to the interiors of cells. The availability of genome sequences from humans and several model organisms has facilitated the identification of several human plasma membrane receptor families and allowed the analysis of their phylogeny. This review provides a global categorization of most known signal transduction-associated receptors as enzymes, recruiters, and latent transcription factors. The evolution of known families of human plasma membrane signaling receptors was traced in current literature and validated by sequence relatedness. This global analysis reveals themes that recur during receptor evolution and allows the formulation of hypotheses for the origins of receptors. The human receptor families involved in signaling (with the exception of channels) are presented in the Human Plasma Membrane Receptome database.

*Corresponding author. E-mail: aaron.hsueh{at}

Citation: I. Ben-Shlomo, S. Yu Hsu, R. Rauch, H. W. Kowalski, A. J. W. Hsueh, Signaling Receptome: A Genomic and Evolutionary Perspective of Plasma Membrane Receptors Involved in Signal Transduction. Sci. STKE 2003, re9 (2003).

Read the Full Text

Endocytosis and Signaling during Development.
C. Bokel and M. Brand (2014)
Cold Spring Harb Perspect Biol 6, a017020
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882