Sci. STKE, 1 July 2003
STRUCTURAL BIOLOGY Following the Assembly of Receptor Complex
Gp130 is a shared signal-transducing receptor for a family of four-helix bundle cytokines including the proinflammatory cytokine interleukin-6 (IL-6). Signaling through the gp130 receptor is critical to the normal growth and differentiation of numerous tissue types. Boulanger et al. have determined the 3.65 angstrom resolution structure of a multicomponent receptor complex comprising human IL-6, the extracellular binding domains of human IL-6 α-receptor (IL-6Rα), and the extracellular activation and binding domains of gp130. The hexamer assembles sequentially; a binary complex between IL-6Rα and IL-6 binds to gp130, and this step facilitates a cooperative transition to the signaling-competent hexamer.
Citation: Following the Assembly of Receptor Complex. Sci. STKE 2003, tw254 (2003).
Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882