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Sci. STKE, 1 July 2003 EDITORS' CHOICESTRUCTURAL BIOLOGY Following the Assembly of Receptor Complex
Gp130 is a shared signal-transducing receptor for a family of four-helix bundle cytokines including the proinflammatory cytokine interleukin-6 (IL-6). Signaling through the gp130 receptor is critical to the normal growth and differentiation of numerous tissue types. Boulanger et al. have determined the 3.65 angstrom resolution structure of a multicomponent receptor complex comprising human IL-6, the extracellular binding domains of human IL-6 M. J. Boulanger, D.-c. Chow, E. E. Brevnova, K. C. Garcia, Hexameric structure and assembly of the interleukin-6/IL-6
Citation: Following the Assembly of Receptor Complex. Sci. STKE 2003, tw254 (2003). |
Science Signaling. ISSN 1937-9145 (pre-2008: Science's STKE. ISSN 1525-8882)