Sci. STKE, 8 July 2003
NEUROBIOLOGY Firing and Wiring
Molecular cues guide the general direction of axon travel between brain areas, but correlated activity likely refines the final connections. To test whether neurons that "fire together, wire together," Ruthazer et al. redirected axons growing from the frog eye so that both eyes would innervate the same optic tectum. In this competitive situation, eye-specific regions were set up in the tectum. Thus, higher correlation among same-eye axons led to connections being formed in adjacent territory. Axons in regions dominated by opposite-eye innervation showed a higher rate of elimination of new branches. A computer simulation reproduced the generation of eye-specific territories resulting from these differing addition and elimination rates.
Citation: Firing and Wiring. Sci. STKE 2003, tw264 (2003).
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