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Sci. STKE, 15 July 2003
Vol. 2003, Issue 191, p. pe27
[DOI: 10.1126/scisignal.1912003pe27]

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A Kelch β Propeller Featuring as a Gβ Structural Mimic: Reinventing the Wheel?

Jan Gettemans*, Kris Meerschaert, Joël Vandekerckhove, and Veerle De Corte

Department of Biochemistry, Faculty of Medicine and Health Sciences, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Rommelaere Institute, Albert Baertsoenkaai 3, B-9000 Ghent, Belgium.

Abstract: New genetic and protein interaction data suggest that G protein α subunits may have partners with primary sequences that are quite divergent. How this is achieved may be through the adoption of similar structures, the β propeller, by both proteins containing WD-40 repeats and kelch domains. Gettemans et al. describe results in yeast that suggest that kelch-domain proteins may serve as previously unrecognized β subunits in the heterotrimeric G protein complex.

*Corresponding author: Telephone, 00 32 9 33 13340; fax, 00 32 9 33 13597; e-mail, jan.gettemans{at}UGent.be

Citation: J. Gettemans, K. Meerschaert, J. Vandekerckhove, V. De Corte, A Kelch β Propeller Featuring as a Gβ Structural Mimic: Reinventing the Wheel? Sci. STKE 2003, pe27 (2003).

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