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Sci. STKE, 22 July 2003 PERSPECTIVESRunning Interference for Hedgehog SignalingDivision of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, 20 Shattuck Street, Boston, MA 02115, USA. Summary: The new technology of RNA interference (RNAi) is allowing high-throughput screening of cells to examine many biological processes. Michelson discusses one such system in which the Drosophila Hedgehog (Hh) pathway was analyzed by systematic genome-wide RNAi analysis. The results not only suggest unexpected overlap in the Hh and Wingless (Wg) pathways, but also provide proof of principle for the development of high-throughput assays using RNAi techniques. *Contact information. Telephone, (617) 732-7411; fax, (617) 738-5575; e-mail, michelson{at}rascal.med.harvard.edu
Citation: A. M. Michelson, Running Interference for Hedgehog Signaling. Sci. STKE 2003, pe30 (2003). The editors suggest the following Related Resources on Science sites:In Science Signaling
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Science Signaling. ISSN 1937-9145 (pre-2008: Science's STKE. ISSN 1525-8882)
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