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Sci. STKE, 22 July 2003
Vol. 2003, Issue 192, p. pe30
[DOI: 10.1126/stke.2003.192.pe30]

PERSPECTIVES

Running Interference for Hedgehog Signaling

Alan M. Michelson*

Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, 20 Shattuck Street, Boston, MA 02115, USA.

Abstract: The new technology of RNA interference (RNAi) is allowing high-throughput screening of cells to examine many biological processes. Michelson discusses one such system in which the Drosophila Hedgehog (Hh) pathway was analyzed by systematic genome-wide RNAi analysis. The results not only suggest unexpected overlap in the Hh and Wingless (Wg) pathways, but also provide proof of principle for the development of high-throughput assays using RNAi techniques.

*Contact information. Telephone, (617) 732-7411; fax, (617) 738-5575; e-mail, michelson{at}rascal.med.harvard.edu

Citation: A. M. Michelson, Running Interference for Hedgehog Signaling. Sci. STKE 2003, pe30 (2003).

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