Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. STKE, 22 July 2003
Vol. 2003, Issue 192, p. pe30
[DOI: 10.1126/stke.2003.192.pe30]


Running Interference for Hedgehog Signaling

Alan M. Michelson*

Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, 20 Shattuck Street, Boston, MA 02115, USA.

Abstract: The new technology of RNA interference (RNAi) is allowing high-throughput screening of cells to examine many biological processes. Michelson discusses one such system in which the Drosophila Hedgehog (Hh) pathway was analyzed by systematic genome-wide RNAi analysis. The results not only suggest unexpected overlap in the Hh and Wingless (Wg) pathways, but also provide proof of principle for the development of high-throughput assays using RNAi techniques.

*Contact information. Telephone, (617) 732-7411; fax, (617) 738-5575; e-mail, michelson{at}

Citation: A. M. Michelson, Running Interference for Hedgehog Signaling. Sci. STKE 2003, pe30 (2003).

Read the Full Text

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882