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Sci. STKE, 5 August 2003
Vol. 2003, Issue 194, p. cm2
[DOI: 10.1126/stke.2003.194.cm2]

CONNECTIONS MAP OVERVIEWS

Dictyostelium discoideum cAMP Receptor, G Protein-Independent Pathways

Alan R. Kimmel1 and Carole A. Parent2*

1Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
2Laboratory of Cellular and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Abstract: Seven-transmembrane receptors can transduce signals in the absence of productive heterotrimeric guanosine triphosphate-binding protein (G protein) interaction. In Dictyostelium discoideum, these signals activate transcriptional, mitogen-activated protein kinase (MAPK), and Ca2+ influx pathways, as well as ligand-stimulated phosphorylation of the receptors themselves. This Connections Map illustrates the pathways that remain active in D. discoideum carrying mutations in various G protein genes.

Science Viewpoint

A. R. Kimmel, C. A. Parent, The signal to move: D. discoideum go orienteering. Science 300, 1525-1527 (2003). [Abstract] [Full Text]

*Corresponding author. E-mail, parentc{at}helix.nih.gov

Citation: A. R. Kimmel, C. A. Parent, Dictyostelium discoideum cAMP Receptor, G Protein-Independent Pathways. Sci. STKE 2003, cm2 (2003).

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Science Signaling. ISSN 1937-9145 (pre-2008: Science's STKE. ISSN 1525-8882)