Sci. STKE, 5 August 2003
DEVELOPMENT Prunin' and Reelin
Reelin plays a significant role during cortical development, but it continues to be expressed after its critical function in directing development of the brain's architecture is over. Quattrocchi et al. now analyze what other processes may involve reelin. Reelin is expressed in mouse neuromuscular junctions in both motor axons and muscle fibers. During development, the initially exuberant innervations of muscle fibers are normally pruned to minimize multiple innervations. In mice lacking reelin, this pruning process is deficient. Reelin function at the neuromuscular junction seems to be through its endogenous protease function, rather than through the Disabled1 signaling pathway that mediates its role in brain development.
C. C. Quattrocchi, C. Huang, S. Niu, M. Sheldon, D. Benhayon, J. Cartwright Jr., D. R. Mosier, F. Keller, G. D'Arcangelo, Reelin promotes peripheral synapse elimination and maturation. Science 301, 649-653 (2003). [Abstract] [Full Text]
Citation: Prunin' and Reelin. Sci. STKE 2003, tw305 (2003).
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