Sci. STKE, 12 August 2003
NEUROSCIENCE Retrograde Transport and ALS Therapy
Amyotrophic lateral sclerosis (ALS) is a fatal disease characterized by degeneration of the motor neurons for which there is no effective therapy. Kaspar et al. now show in a mouse model of ALS that injecting an adeno-associated viral vector carrying the neurotrophic factor, insulin growth factor 1 (IGF-1), into mouse limb muscles delays disease progression and prolongs survival of the animals. Travel of the viral vector by retrograde transport along the motor neurons that innervate the muscles delivered IGF-1 to the neuronal cell bodies.
Citation: Retrograde Transport and ALS Therapy. Sci. STKE 2003, tw320 (2003).
The editors suggest the following Related Resources on Science sites:
In Science Magazine
Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882