Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
STEM Talent Event

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Sci. STKE, 26 August 2003
Vol. 2003, Issue 197, p. cm14
[DOI: 10.1126/stke.2003.197.cm14]

CONNECTIONS MAP OVERVIEWS

The IFN-{gamma} Pathway

David S. Aaronson and Curt M. Horvath*

Immunobiology Center, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA.

Abstract: The interferon-gamma (IFN-{gamma}) signal transduction pathway closely resembles the canonical Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway. The IFN-{gamma} Pathway is thus a paradigm for most other JAK-STAT pathways that result in dimerization of STAT transcription factors in response to phosphorylation, including the mammalian STAT4, STAT5A, STAT5B, and STAT6, as well as orthologous systems in various organisms. IFN-{gamma} is a crucial component of innate and adaptive immunity. The Connections Map shows activation of STAT1 by JAK1 and JAK2 and includes several negative regulators of the pathway.

Science Viewpoint

D. S. Aaronson, C. M. Horvath, A road map for those who don't know JAK-STAT. Science 296, 1653-1655 (2002). [Abstract] [Full Text]

*Corresponding author. E-mail, curt.horvath{at}mssm.edu

Citation: D. S. Aaronson, C. M. Horvath, The IFN-{gamma} Pathway. Sci. STKE 2003, cm14 (2003).

ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (pre-2008: Science's STKE. ISSN 1525-8882)