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Sci. STKE, 26 August 2003 EDITORS' CHOICEPLANT BIOLOGY Overcoming Negatives in Auxin RegulationThe plant hormone auxin is a key regulator of growth and development. Zhao et al. identified a compound, sirtinol, that stimulates biological responses similar to those initiated by auxin. They then screened for mutants of Arabidopsis that did not respond to sirtinol and identified a mutant they called sir1 that encodes a protein with similarity to a ubiquitin-activating E1-like protein. This result may help explain how auxin can rapidly degrade negative regulators as part of its mechanism of action. Y. Zhao, X. Dai, H. E. Blackwell, S. L. Schreiber, J. Chory, SIR1, an upstream component in auxin signaling identified by chemical genetics. Science 301, 1107-1110 (2003). [Abstract] [Full Text]
Citation: Overcoming Negatives in Auxin Regulation. Sci. STKE 2003, tw336 (2003). The editors suggest the following Related Resources on Science sites:In Science Magazine
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