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Sci. STKE, 2 September 2003
Vol. 2003, Issue 198, p. tr3
[DOI: 10.1126/stke.2003.198.tr3]


Synaptic Vesicle Fusion Followed by Clathrin-Mediated Endocytosis

Thierry Galli1, Volker Haucke2, and Nancy R. Gough3*

1 Membrane Traffic and Neuronal Plasticity Group, INSERM U536, Institut du Fer-à-moulin, 75005 Paris, France.
2 Zentrum Biochemie & Molekulare Zellbiologie, University of Göttingen, D-37073 Göttingen, Germany.
3Science's STKE, American Association for the Advancement of Science, 1200 New York Avenue, N.W., Washington, DC 20005, USA.

Abstract: The animation shows calcium-stimulated exocytosis of synaptic vesicles followed by clathrin-mediated vesicle recycling. Many of the molecular components that are involved in synaptic vesicle priming, docking, fusion, and endocytosis are shown. Although the process in the animation describes synaptic vesicle cycling, similar cellular processes occur for most calcium-coupled secretory and clathrin-mediated endocytotic events. The animation could be used to help illustrate the sequence of events associated with both exocytosis and endocytosis, as well as aid in understanding the processes involved in neurotransmitter release in response to nerve stimulation.

[Resource Details]

*Corresponding author. E-mail: ngough{at}

Citation: T. Galli, V. Haucke, N. R. Gough, Synaptic Vesicle Fusion Followed by Clathrin-Mediated Endocytosis. Sci. STKE 2003, tr3 (2003).

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