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Sci. STKE, 2 September 2003 TEACHING RESOURCESTrans-Endocytosis of Notch Receptors into Ligand-Expressing CellsHelmut Krämer1 and Nancy R. Gough2*
1Center for Basic Neuroscience and Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75235-9111, USA. Abstract:
The animation shows a schematic representation of how trans-endocytosis of Notch into Delta-expressing cells contributes to Notch activation. Notch proteins are receptors that mediate several developmental processes. Notch receptors are activated upon binding transmembrane ligands of the DSL family, such as Delta ( *Corresponding author. E-mail: ngough{at}aaas.org
Citation: H. Krämer, N. R. Gough, Trans-Endocytosis of Notch Receptors into Ligand-Expressing Cells. Sci. STKE 2003, tr4 (2003). The editors suggest the following Related Resources on Science sites:In Science Signaling
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). Following ligand binding, Notch is cleaved twice. First, Notch is cleaved in its extracellular domain at the S2 site. The subsequent cleavage within Notch's transmembrane domain at the S3 site releases an intracellular domain (N-ICD), which translocates into the nucleus and regulates the transcription of target genes. The cleavage and trans-endocytosis of the Notch extracellular domain (N-ECD) into the ligand-expressing cell facilitates release of the N-ICD.
Science Signaling. ISSN 1937-9145 (pre-2008: Science's STKE. ISSN 1525-8882)
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