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Sci. STKE, 2 September 2003
Vol. 2003, Issue 198, p. tr4
[DOI: 10.1126/stke.2003.198.tr4]


Trans-Endocytosis of Notch Receptors into Ligand-Expressing Cells

Helmut Krämer1 and Nancy R. Gough2*

1Center for Basic Neuroscience and Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75235-9111, USA.
2Science's STKE, American Association for the Advancement of Science, 1200 New York Avenue, N.W., Washington, DC 20005, USA.

Abstract: The animation shows a schematic representation of how trans-endocytosis of Notch into Delta-expressing cells contributes to Notch activation. Notch proteins are receptors that mediate several developmental processes. Notch receptors are activated upon binding transmembrane ligands of the DSL family, such as Delta ({delta}). Following ligand binding, Notch is cleaved twice. First, Notch is cleaved in its extracellular domain at the S2 site. The subsequent cleavage within Notch's transmembrane domain at the S3 site releases an intracellular domain (N-ICD), which translocates into the nucleus and regulates the transcription of target genes. The cleavage and trans-endocytosis of the Notch extracellular domain (N-ECD) into the ligand-expressing cell facilitates release of the N-ICD.

[Resource Details]

*Corresponding author. E-mail: ngough{at}

Citation: H. Krämer, N. R. Gough, Trans-Endocytosis of Notch Receptors into Ligand-Expressing Cells. Sci. STKE 2003, tr4 (2003).

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