Sci. STKE, 16 September 2003
STRUCTURAL BIOLOGY A Light-Sensing Protein Motif
Phototropins are plant proteins that respond to blue light and regulate processes such as phototropism and leaf opening. On exposure to light, a per-ARNT-Sim (PAS) domain forms a covalent bond with a flavin chromophore, and this process somehow activates a kinase domain. Harper et al. used nuclear magnetic resonance spectroscopy to show that an α-helix located outside of the PAS domain core associates with the domain in the dark, but the interaction is disrupted in the illuminated state. This conformational change likely couples light-dependent bond formation to kinase activation.
Citation: A Light-Sensing Protein Motif. Sci. STKE 2003, tw365 (2003).
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