Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Subscribe

Sci. STKE, 23 September 2003
Vol. 2003, Issue 201, p. pe40
[DOI: 10.1126/scisignal.2012003pe40]

PERSPECTIVES

The Cytokine Receptor gp130: Faithfully Promiscuous

Gerhard Müller-Newen*

Institut für Biochemie, Universitätsklinikum RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany.

Abstract: Diverse cytokines can signal through receptor complexes containing the gp130 subunit. These cytokines, which include interleukin (IL)-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1), and CLC (cardiotrophin-like cytokine), are implicated in inflammatory and immune responses, heart development, and fertility. The gp130 receptor-ligand complexes are contrasted with the complex formed by erythropoietin (Epo) and its receptor, EpoR. Also discussed are insights provided by the structural analysis of IL-6, its α receptor (IL6Rα), and the signal transducer gp130 for understanding receptor-ligand assembly, for predicting the structures of ligand-receptor complexes of the other IL-6-type cytokines, and for rational drug design.

*Contact information. Telephone, +49-241-80-88860; fax, +49-241-80-82428; e-mail, mueller-newen{at}rwth-aachen.de

Citation: G. Müller-Newen, The Cytokine Receptor gp130: Faithfully Promiscuous. Sci. STKE 2003, pe40 (2003).

Read the Full Text

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Characterization of the Interleukin (IL)-6 Inhibitor IL-6-RFP: FUSED RECEPTOR DOMAINS ACT AS HIGH AFFINITY CYTOKINE-BINDING PROTEINS.
S. Metz, M. Wiesinger, M. Vogt, H. Lauks, G. Schmalzing, P. C. Heinrich, and G. Muller-Newen (2007)
J. Biol. Chem. 282, 1238-1248
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882